Glucagon-like peptide-1 (GLP-1) receptor agonist has emerged as a promising medication for managing obesity due to its efficacy in promoting weight loss when used at higher doses. Originally developed as a treatment for type 2 diabetes, this class of drug works by mimicking the effects of GLP-1, a hormone that helps regulate blood sugar levels and appetite.
Clinical Trials
Clinical trials have demonstrated that GLP-1 can lead to significant weight loss in individuals with obesity when combined with lifestyle modifications such as a healthy diet and regular exercise. The weight loss achieved with GLP-1 has been shown to be greater compared to placebo or other weight loss medications. Clinical trials, like the STEP study are proof of the safety and effectiveness of the GLP-1 in treating people with obesity. Patients taking 2.4 mg of the GLP-1 drug lost an average of 6% of their body weight by week 12 and 12% by week 28. In another study with 2000 participants with obesity, 20% of body weight loss occurred after 68 weeks.
The impressive weight loss results explain why the GLP-1 is one of the most talked about medications in the field of obesity health and medical-managed weight loss. Furthermore, its popularity has extended to celebrities.
Here are some key points about GLP-1 when deciding if it’s right for you:
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- Clinical Trials: Large clinical trials have shown that GLP-1 can lead to significant weight loss. Participants in these studies have often experienced a reduction in body weight of around 15-20% over a year.
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- Appetite Regulation: The drug mimics the hormone GLP-1, which helps regulate appetite and food intake, reducing hunger and caloric consumption.
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- Cardiovascular Benefits: Beyond weight loss, GLP-1 has also been associated with improvements in cardiovascular health, which is particularly beneficial for obese individuals who are at higher risk for heart disease.
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- FDA Approval: In 2021, the FDA approved the GLP-1 for chronic weight management under a brand name, highlighting its recognized effectiveness and safety for this purpose.
Mechanism The GLP-1 capacity to slow gastric emptying directly aids in weight management by prolonging digestion, thereby increasing the feeling of fullness faster and longer, therefore silencing the food noise and decreasing appetite. The power of appetite regulation makes this medication appealing to many people suffering from chronic obesity and binge eating. Additionally, the weight loss shots may also affect the way the body stores and utilizes fat, contributing to its weight loss effects.
Precautions and contraindications It’s important to know that like any medication, GLP-1 may not be suitable for everyone and can have potential side effects. Common side effects of the medications include nausea, vomiting, bloating, diarrhea, constipation, reflux, dizziness, and fatigue. GLP-1 is contraindicated in patients with a personal or family history of Medullary Thyroid Carcinoma (MTC), patients with Multiple Endocrine Neoplasia Syndrome Type 2 (MEN 2), and patients with a history of hypersensitivity reaction to GLP-1. Due to the risk of fetal harm, these drugs should be avoided in women who are pregnant or breastfeeding. In clinical trials, participants over the age of 75 reported more fractures than the placebo group. More serious side effects may also occur, so it is crucial to consult with a healthcare provider before starting the weight loss therapy, and we are ready to answer your questions, here at Grateful Healthcare.
Backed by Science
At Grateful Healthcare, we support the science behind GLP-1 and recognize that this is a fantastic option for treating obesity. If you’re interested in learning more and would like to know if you’re a candidate for GLP-1, feel free to contact Grateful Healthcare https://gratefulhc.com/ for a consultation with a weight loss nurse practitioner.